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See the USADA insert

These include diabetes or high blood pressure that is not well managed anticoagulation or bleeding disorder allergies or hypersensitivity to steroid medication or anesthesia infection at the site of the injection congestive heart failure While doctors consider spinal injections generally safe, severe complications may occur in rare cases

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It requires specific modulation to calm down and regain tolerance

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Never skip dose-range pilot studies peptide dose-response relationships are often non-linear and can be U-shaped 6